Is material transmitting cosuppression RNA ?

Transgenes are dispensable for the RNA degradation step of cosuppression.

Cosuppression results in the degradation of RNA from host genes and homologous transgenes after transcription in the nucleus. By using grafting experiments, we have shown previously that a systemic signal mediates the propagation of cosuppression of Nia host genes and 35S-Nia2 transgenes from silenced 35S-Nia2 transgenic stocks to nonsilenced 35S-Nia2 transgenic scions but not to wild-type scio...

Prosecuting for knowingly transmitting HIV is warranted.

Cosuppression Comes to the Animals

during the last eight years has revealed a set of phenomIn addition to mechanistic heterogeneity, these pheena, under diverse names, that will be referred to here nomena show variability in developmental timing. Cocollectively as cosuppression. In all cases of cosuppressuppression in plants occurs somatically, though the sion, the presence of supernumary (two or more) copies repressed state can...

Arabidopsis mutants impaired in cosuppression.

Post-transcriptional gene silencing (cosuppression) results in the degradation of RNA after transcription. A transgenic Arabidopsis line showing post-transcriptional silencing of a 35S-uidA transgene and uidA-specific methylation was mutagenized using ethyl methanesulfonate. Six independent plants were isolated in which uidA mRNA accumulation and beta-glucuronidase activity were increased up to...

Transgene-mediated cosuppression and RNA interference enhance germ-line apoptosis in Caenorhabditis elegans.

Introduction of multiple copies of a germ-line-expressed gene elicits silencing of the corresponding endogenous gene during Caenorhabditis elegans oogenesis; this process is referred to as germ-line cosuppression. Transformed plasmids assemble into extrachromosomal arrays resembling extra minichromosomes with repetitive structures. Loss of the transgene extrachromosomal array leads to reversion...